INTRODUCTION
multc97 is a menu-driven program which provides all necessary
computations for implementing the design strategy for monitoring
multiple outcomes in clinical trials described in the following
three papers.
Thall, Peter F., Simon, R. and Estey, E.H. "Bayesian sequential
monitoring designs for single-arm clinical trials with multiple
outcomes," Statistics in Medicine 14:357-379, 1995.
Thall, Peter F., Simon, R. and Estey, E.H. "New statistical strategy
for monitoring safety and efficacy in single-arm clinical trials," J.
Clinical Oncology 14:296-303, 1996.
Thall, Peter F. and Sung, Hsi-Guang, "Some Extensions and Applications
of a Bayesian Strategy for Monitoring Multiple Outcomes in Clinical
Trials,"
(submitted for publication).
HOW IT WAS WRITTEN
multc97 was written in ANSI C, compiled by GNU C compiler gcc. All the
examples in the paper (*) were run on a DEC Alpha machine.
LEGALITIES (BRIEF)
We want to make this program as widely available as possible.
Hence, executable code derived from the source provided, the source
itself, and the accompanying documentation may be freely copied and
distributed provided that this copyright section accompanies such
copies. We encourage the distribution of this code on bulletin boards
and as shareware.
Modifications and improvements to the code can similarly be freely
copied and distributed. Peter F. Thall and Hsi-Guang Sung would
appreciate a copy of any such improvements for incorporation into
later versions of multc97.
Source code may be extracted and used for any non-commercial
purpose. Non-commercial means that at most a modest distribution fee
is charged, as shareware. We would appreciate acknowledgment of such
use of our code.
Commercial use of the source code requires written permission from
the Department of Biomathematics at the above address. Our policy is
generally to grant such permission provided appropriate credit is
given to us in the documentation.
INSTALLATION
For step-by-step instructions, please see the file 'INSTALL'. Sample
sessions and tutorials can be found in file 'Examples'.
OBTAINING SOURCE AND OTHER VERSIONS
The C source code is available via anonymous ftp from
odin.mdacc.tmc.edu (129.106.1.6) in the subdirectory /pub/source.
The current version is for UNIX.
MS-DOS PC and MacIntosh executables will be available in the near future.
CONTACTING THE AUTHORS
To contact the authors of multc97 or report any bugs, please write to:
Peter F. Thall
Department of Biomathematics, Box 237
University of Texas M. D. Anderson Cancer Center
1515 Holcombe Boulevard
Houston, TX 77030
or send electronic mail to:
rex@odin.mdacc.tmc.edu
